The request was approved on and is valid till. The University of New Mexico Health Sciences Center Human Research Review Committee waived the requirements for informed consent and HIPAA authorization addendum. The details of the IRB/oversight body that provided approval or exemption for the research described are given below: I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Saeed K Shaffi: The University of New Mexico Kidney biopsy registry was established by funding from the Dialysis Clinic, Inc. Saeed Kamran Shaffi: Advisory board: NovartisĬhristos Argyropoulos: Consultant Agreements: Bayer, Baxter, Otsuka, Quanta A diverse development population may improve the risk prediction. At 5 years, the agreement between the observed and predicted outcomes was sub-optimal, possibly due to advanced kidney disease in this cohort. Ĭonclusions: The International IgAN risk prediction equation without race accurately identified patients at elevated risk of developing kidney failure. Overall prediction error was suboptimal in this cohort. The agreement between observed and predicted outcomes at 5 years was marginal, with over-estimation of risk for patients with low observed risk and vice versa. The equation identified patients at high risk of developing kidney failure early with a concordance statistic of 0.79 (95% CI 0.68-0.89). At biopsy, the median (IQR) age, serum creatinine, and spot urine protein to creatinine ratio were 38 years (27-45), 2.15 mg/dl (1.51-3.04), and 2.7 g/g (1.5-5.8), respectively. Results: Thirty-four patients were included, most of whom identified as of Hispanic race/ethnicity (44.1%), or as American Indians (26.5%). Methods: We calculated the 5-year risk of developing kidney failure with the IgAN risk prediction equation without race and assessed the equation performance using the metrics of calibration, discrimination, and overall prediction error. We conducted a single-center study to assess the equation performance in this population. ![]() ![]() ![]() The performance of this risk prediction tool has not been studied in American Indians and Hispanics. Background: The International Immunoglobulin A nephropathy (IgAN) risk prediction assesses the risk of kidney failure in patients with IgAN.
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